Microfluidic organs-on-chips

By Sangeeta N. Bhatia, Donald E. Ingber. Nature Biotechnology, 2014

2,897 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e33fe81a69c95f218a9e2515feee9962b8fb5bcb

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In Molecular Biology

Citations in the corpus

The Emerging Frontiers and Applications of High-Resolution 3D Printing (2017, background): “Compared with the previous biomimetic microsystems which were not well suitable for higher-throughput or longer-term studies [111,112], the novel system of 3D printed instrumented cardiac microphysiological devices would drastically simplify data acquisition and leverage the ability to track the tem”
Three-dimensional bioprinting of thick vascularized tissues (2016, background): “T ability to manufacture human tissues that replicate the essential spatial (1), mechanochemical (2, 3), and temporal aspects of biological tissues (4) would enable myriad applications, including 3D cell culture (5), drug screening (6, 7), disease modeling (8), and tissue repair and regeneration (9,”
Instrumented cardiac microphysiological devices via multi-material 3D printing (2016, neutral): “17 Although these assays have proven valuable for short-term modeling of human disease and 18 small-scale drug screening applications [1, 5, 6], they are not well suited for higher throughput or 19”
Three-dimensional femtosecond laser processing for lab-on-a-chip applications (2018, background): “Several advantages of PDMS include biocompatibility, transparency, and ease of use, but it exhibits also some disadvantages such as nonreusability, requirement of multiple stacking processing, and adsorbant of organic compounds [21].”
Stem Cell Organoid Engineering (2016, neutral): “Miniaturized models of functional biological units have already been fabricated on a chip, including models for lung, liver, kidney, intestine, heart, fat, bone marrow, cornea, skin, and the blood-brain barrier (see Bhatia and Ingber, 2014 for review).”
Microfluidic Devices for Drug Delivery Systems and Drug Screening (2018, background): “micro-chamber to pattern the physiological functions of tissues and organs [153].”
Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors (2017, background): “These miniaturized human organ models have several advantages over conventional models, such as more accurate prediction of human responses and, in particular, multiorgan interactions when different organ modules are assembled in a single fluid circuit (7, 31).”