Elucidation of the Methylerythritol Phosphate Pathway for Isoprenoid Biosynthesis in Bacteria and Plastids. A Metabolic Milestone Achieved through Genomics1

By M. Rodríguez‐Concepción, A. Boronat. Plant Physiology, 2002

823 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e312d19622d0d78e1f7a862b6cd5843f2c560ed9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Carotenoid metabolism in plants. (2015, neutral): “Two pathways exist for IPP production in plants: the cytosolic mevalonic acid pathway (MVA) and the plastidic methylerythritol 4-phosphate (MEP) pathway (Rodriguez-Concepcion and Boronat, 2002; Eisenreich et al., 2004).”
A golden era—pro-vitamin A enhancement in diverse crops (2011, background): “IPP and DMAPP are derived predominantly from the plastidial methylerythritol 4-phosphate (MEP) pathway (Rodriguez-Concepcion and Boronat 2002), although the same precursors are formed by the cytosolic mevalonic acid pathway, and there is some evidence for the shuttling of intermediates between pathw”
Gibberellin biosynthesis and inactivation (2010, background): “The MEP pathway for the production of trans-geranylgeranyl diphosphate (GGPP) in plastids is shown in Fig. 5, and its elucidation in Eubacteria is described in several reviews (12, 55 ).”
Regulation and Manipulation of the Biosynthesis of Abscisic Acid, Including the Supply of Xanthophyll Precursors (2005, background): “All of the genes encoding these ‘‘early’’ MEP pathway enzymes in bacteria and in plants have been identified (reviewed by Rodriguez-Concepcion and Boronat 2002).”
Abscisic acid biosynthesis and catabolism. (2005, background): “Plastidic isoprenoids, including carotenoids, originate from IDP synthesized from this MVA-independent pathway, called the 2-C-methyl-d-erythritol-4phosphate (MEP) pathway (24, 89).”
Cellular and sub-cellular organisation of the monoterpenoid indole alkaloid pathway in Catharanthus roseus (2007, background): “The MEP pathway is a novel plastidic pathway involved in the production of isopentenyl diphosphate (IPP), previously thought to be solely synthesised via the cytosolic mevalonate pathway (Lichtenthaler et al. 1997; Lichtenthaler 1999; Rodrı́guez-Concepción and Boronat 2002).”
Metabolic Engineering of Terpenoid Biosynthesis in Plants (2006, background): “4-phosphate (MEP) pathway is active in the plastids (Mahmoud and Croteau, 2002; Rodriguez-Concepcion and Boronat, 2002 ).”
Diversity and distribution of floral scent (2006, background): “The terpenes themselves are formed from C5 isopentanoid building blocks synthe- sized by the mevalonate or methylerythritol 4-phosphate (MEP) pathways (Gershenzon & Kreis, 1999; Rodriguez-Concepcion & Boronat, 2002).”
The Human Urine Metabolome (2013, background): “2-methylerythritol-4phosphate is an intermediate in isoprenoid biosynthesis [74] and has been found to be quite abundant in certain plants [75].”
Water deficit effect on the accumulation of biomass and artemisinin in annual wormwood(Artemisia annua L., Asteraceae) (2010, background): “Despite the fact that the terpenes biosynthetic pathway has been characterized in some detail at the molecular level over the last two decades, its regulation during plant responses to drought stress is still poorly understood (Rodríguez-Concepción and Boronat, 2002; Liu et al., 2005).”
Plant Volatiles: Recent Advances and Future Perspectives (2006, methodology): “In plastids, DMAPP generated from the MEP pathway is used by isoprene synthases (Silver and Fall, 1995; Schnitzler et al., 1996; Miller et al., 2001) for isoprene formation (Schwender et al., 1997; Rodriguez-Concepción and Boronat, 2002).”