CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.

By T. Hamblin, J. Orchard, R. Ibbotson, Z. Davis, P. Thomas, F. Stevenson, D. Oscier. Blood, 2002

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Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. (2008, neutral): “(53, 117, 133, 137), and 2) the feasibility of using cryo-”
Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (2015, neutral): “About 50% of CLL patients present with an unmutated IGHV status [14, 15].”
ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. (2003, background): “Subsequent studies have not always shown this relationship.(20,21) It has also been suggested that CD38 expression might add to the prognostic information in patients with known IgVH status(20), but two large studies that together included more than 500 patients failed to confirm CD38 as an independ”