Aging and Osteoarthritis: The Role of Chondrocyte Senescence and Aging Changes in the Cartilage Matrix
By Richard F. Loeser. Osteoarthritis and Cartilage, 2009
712 citations recorded by the source corpus.
Summary Objective Age-related changes in multiple components of the musculoskeletal system may contribute to the well established link between aging and osteoarthritis (OA). This review focused on potential mechanisms by which age-related changes in the articular cartilage could contribute to the development of OA. Methods The peer-reviewed literature published prior to February 2009 in the PubMed database was searched using pre-defined search criteria. Articles, selected for their relevance to aging and articular chondrocytes or cartilage, were summarized. Results Articular chondrocytes exhibit an age-related decline in proliferative and synthetic capacity while maintaining the ability to produce pro-inflammatory mediators and matrix degrading enzymes. These findings are characteristic of the senescent secretory phenotype and are most likely a consequence of extrinsic stress-induced senescence driven by oxidative stress rather than intrinsic replicative senescence. Extracellular matrix changes with aging also contribute to the propensity to develop OA and include the accumulation of proteins modified by non-enzymatic glycation. Conclusion The effects of aging on chondrocytes and their matrix result in a tissue that is less able to maintain homeostasis when stressed, resulting in breakdown and loss of the articular cartilage, a hallmark of osteoarthritis. A better understanding of the basic mechanisms underlying senescence and how the process may be modified could provide novel ways to slow the development of osteoarthritis.
Subfields: Molecular Biology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/e2e7a38ae45377a99aa6e0570f0040c3d0616616
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
Citations in the corpus
- The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. (2020, background): “In aging articular cartilage, chondrocytes exhibit an age-related decline in proliferative and synthetic capacity while maintaining the ability to produce pro-inflammatory mediators and matrix degrading enzymes (Loeser, 2009).”
- Senescence and aging: Causes, consequences, and therapeutic avenues (2018, neutral): “, 2014), chondrocytes (Loeser, 2009), adipocytes (Tchkonia et al.”
- Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory (2019, background): “In OA, chondrocytes serve as mechanosensors and osmosensors, and their metabolism is influenced by microenvironment that in return influences ECM composition, organization and ultimately the mechanical resilience of cartilage (110, 209, 210).”