Ubiquitin‐mediated proteolysis: biological regulation via destruction

By Aaron Ciechanover, A. Orian, A. Schwartz. Bioessays, 2000

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Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease (2001, background): “Short-lived and 'abnormal' proteins are targeted by ubiquitination for removal by the 26S proteasom”
Posttranslational Protein Modification in Archaea (2005, background): “In Eucarya, proteins are targeted for proteasomal degradation by the posttranslational covalent attachment of ubiquitin, a 76-amino-acid-residue polypeptide (69).”
Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives (2011, background): “From the E2- to the E3-bound substrate, the activated ubiquitin can then be transferred directly or via a third high energy thiol-ester intermediate [22, 33].”
A proteomics approach to understanding protein ubiquitination (2003, background): “Phosphorylation of some proteins is known to be a prerequisite for ubiquitination and subsequent substrate degradatio”