Cell biology of astrocyte-synapse interactions
By N. J. Allen, C. Eroglu. Neuron, 2017
861 citations recorded by the source corpus.
Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of brain development and physiology through dynamic and often bidirectional interactions with neuronal synapses. Despite the clear importance of astrocytes for the establishment and maintenance of proper synaptic connectivity, our understanding of their role in brain function is still in its infancy. We propose that this is at least in part due to large gaps in our knowledge of the cell biology of astrocytes and the mechanisms they use to interact with synapses. In this review, we summarize some of the seminal findings that yield important insight into the cellular and molecular basis of astrocyte-neuron communication, focusing on the role of astrocytes in the development and remodeling of synapses. Furthermore, we will pose some pressing questions that need to be addressed to advance our mechanistic understanding of the role of astrocytes in regulating synaptic development.
Subfields: Cell Biology, Cellular and Molecular Neuroscience, Developmental Neuroscience
View Paper: https://www.semanticscholar.org/paper/c06190a3768c7294e0dfa2fc2a3a93ea56b9afc3
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Developmental Neuroscience
Citations in the corpus
- Astrocyte crosstalk in CNS inflammation (2020, background): “Astrocytes provide critical trophic support for neurons and play essential roles in health and development (Allen et al., 2012a; Allen and Barres, 2009; Allen and Eroglu, 2017; Christopherson et al., 2005; Chung et al., 2015).”