The cells and logic for mammalian sour taste detection

By Angela L. Huang, Xiaoke Chen, M. Hoon, Jayaram Chandrashekar, Wei Guo, Dimitri Tränkner, N. Ryba, C. Zuker. Nature, 2006

756 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Common Sense about Taste: From Mammals to Insects (2009, background): “Sour-sensing cells are defined by the expression of PKD2L1 (Huang et al., 2006), whereas gustatory responses to carbonation are mediated by the membrane-tethered carbonic anhydrase CA IV (Chandrashekar et al.”
The cell biology of taste (2010, background): “Primary signals in presynaptic cells are only generated by sour tastants, and this is the only quality that is lost when pre synaptic cells are ablated (Huang et al., 2006).”
Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. (2009, neutral): “, 2007) and have also been implicated in gustatory detection of acids (Huang et al., 2006; Ishimaru et al., 2006).”
The receptors and cells for mammalian taste (2006, background): “However, recent genetic and functional studies have greatly simplified the quest for the sour receptor by demonstrating that a member of the TRP ion-channel family, PKD2L1, demarcates sour-sensing TRC”
TRP Channels (2012, neutral): “However the effect of Trpv2 knockout in mice on thermal responsiveness has not yet been published, and preliminary ﬁndings indicate that TRPV2 has no obvious role in heat .”