Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice

By J. Martínez‐Botas, John B. Anderson, Darin Tessier, A. Lapillonne, B. Chang, M. Quast, D. Gorenstein, Kuang-hua Chen, L. Chan. Nature Genetics, 2000

605 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/e1fc467b639bd7e0f60f11ff90fe50792b2e3059

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Citations in the corpus

• PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores (2009, background): “Data from perilipin knockout mice are consistent with this model as such mice show increased basal and decreased stimulated lipolysis [56,57].”
• Regulation of lipolysis in adipocytes. (2007, positive): “Perilipin-null mice have constitutively elevated basal lipolysis, resulting in a marked reduction in WAT mass and smaller adipocyte size (78,106,127).”
• Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. (2005, background): “Lack of perilipin results in lean mice with increased lipolysis and reverses the obese phenotype of leptin receptordeficient mutants (Martinez-Botas et al., 2000; Tansey et al., 2001).”