Specificity in two-component signal transduction pathways.

By M. Laub, M. Goulian. Annual Review of Genetics, 2007

766 citations recorded by the source corpus.

Subfields: Ecology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e1bef6934bb7b6a772388b5986d9ee2a74fd3abf

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Citations in the corpus

Connecting the Sequence-Space of Bacterial Signaling Proteins to Phenotypes Using Coevolutionary Landscapes (2016, background): “An important example is two-component signaling (TCS) (Hoch 2000; Stock et al. 2000; Laub and Goulian 2007; Casino et al. 2010; Szurmant and Hoch 2010; Capra and Laub 2012), which serves as the primary means for bacteria to sense the environment and carry out appropriate responses.”
Biological Insights from Structures of Two-Component Proteins (2009, background): “The capability of decreasing the level of RR phosphorylation through rapid dephosphorylation provides a swift mechanism to shut down the signaling pathway and is suggested to be important for suppressing cross-talk from nonspecific phosphorylation (1, 53).”
Fast and Accurate Multivariate Gaussian Modeling of Protein Families: Predicting Residue Contacts and Protein-Interaction Partners (2014, neutral): “The same (homologous) phosphotransfer mechanism is used for several signaling pathways in each bacterium; thus, to produce the correct cellular response to an external signal, interactions have to be highly specific inside each pathway: crosstalk between pathways has to be avoided [35–37].”
Toward rationally redesigning bacterial two-component signaling systems using coevolutionary information (2014, neutral): “4 and 5).”
The Evolution of Two-Component Signal Transduction Systems (2012, background): “Despite early suggestions of rampant cross-talk, there is little evidence for such promiscuity in vivo, with most kinases having one response regulator substrate or, on occasion, two or three (43, 74, 93).”
Rewiring the specificity of two-component signal transduction systems. (2008, neutral): “Please cite this article in press as: Skerker et al., Rewiring the Specificity of Two-Component Signal Transduction Systems, Cell (2008), doi:10.1016/j.cell.2008.04.040 pathways (reviewed by Laub and Goulian (2007).”
Inferring interaction partners from protein sequences (2016, methodology): “Using these interaction energies, we predict protein pairs [assuming one-to-one specific HK−RR interactions (28), Fig.”
Identification of direct residue contacts in protein–protein interaction by message passing (2009, background): “spartate residue on the RR (25). The SK and RR proteins are believed to interact specifically in most cases, and the coupled pairs are often revealed by adjacency in chromosomal location (reviewed in (26)). Over 2500 such coupled SK-RR pairs have been identified from ~300 sequenced bacterial genomes”
Microbial Surface Colonization and Biofilm Development in Marine Environments (2015, background): “On average, a single microbial species usually possesses 50 TCSs (382), and some bacteria possess hundreds of TCSs operating in parallel for the adaptive response to diverse environmental conditions (365).”
Dissecting the Specificity of Protein-Protein Interaction in Bacterial Two-Component Signaling: Orphans and Crosstalks (2011, background): “TCS pathways are believed to involve a unique pair of SK/RR proteins [4,5].”
Molecular communication in the rhizosphere (2009, background): “Finally, dephosphorylation of the response regulator brings the system back to the prestimulus state (Laub and Goulian 2007).”