Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.

By Weibo Cai, Dong-Woon Shin, Kai Chen, O. Gheysens, Qizhen Cao, Shan X. Wang, Sanjiv Sam Gambhir, Xiaoyuan Chen. Nano letters (Print), 2006

906 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e19e0e8181d1e08de44fe9de081c0c36a4641c2f

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Citations in the corpus

Molecular imaging in drug development (2008, methodology): “Near-infrared fluorescence dye and quantum-dot conjugated cyclic RGD peptides were also used for visualization of subcutaneously inoculated α v β 3 integrin-positive tumour”
Effects of nanomaterial physicochemical properties on in vivo toxicity (2009, background): “, labeling neoplastic cells, peroxisomes, DNA, and cell membrane receptors) after conjugation with specific bioactive moieties [80-85].”
Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation (2010, background): “QDs have been used extensively in in vivo imaging as a replacement for small-molecule organic fluorophores and have been used to track biochemical processes and cancer metastases in living animals.(8,77,78) Compared to conventional small-molecule organic fluorophores, QDs often exhibit higher photos”
Preclinical Whole-body Fluorescence Imaging: Review of Instruments, Methods and Applications (2009, positive): “used a peptide labeled quantum dot that specifically binds to ανβ3 integrin receptor in vivo [75], and another report detected tumor vasculature by a multispectral unmixing technique in a RFP-expressing tumor [76].”
Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy (2008, result): “Because bone marrow is part of the RES, uptake of SWNTs in the bone is understandable and consistent with the previous biodistribution study for other nanomaterials (27).”
An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites (2019, background): “[54] Earlier work on vascular targeting were reported in the 1920s,[55] it was only in 1993 that researchers proved the real potential of this approach with a successful tumour eradication in vivo[56] Then several literature reports extended the concept using ligands like vascular endothelial growth”
Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles (2010, background): “Peptide modification can also be carried by covalent conjugation chemistry, as demonstrated for qantum dots with amino groups (Cai et al. 2006) or magnetic iron oxide nanoparticles (Josephson et al. 1999; Zhao et al. 2002a; Schellenberger et al. 2004).”