Regulatory networks defining EMT during cancer initiation and progression

By B. Craene, G. Berx. Nature Reviews. Cancer, 2013

2,417 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/e1717451d45042cf1dc087cf358e8db9a9552813

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. R. Weinberg
2. M. Nieto
3. Jing Yang
4. D. Medici
5. D. Pattabiraman
6. David M. Gonzalez
7. J. Tsai
8. S. Alahari

In Oncology

1. M. Nieto
2. R. Weinberg
3. Jing Yang
4. D. Pattabiraman
5. D. Medici
6. David M. Gonzalez
7. Arthur W. Lambert
8. J. Tsai

Citations in the corpus

• Epithelial–mesenchymal plasticity in carcinoma metastasis (2013, background): “Given that a number of recent reviews have focused on the molecular pathways regulating EMT/MET (Thiery et al. 2009; De Craene and Berx 2013; Zheng and Kang 2013), this section aims to provide an overview of the cellular and molecular definition for EMT/MET and establish a foundation for detailed…”
• EMT and tumor metastasis (2015, neutral): “6% Snail, Twist, Zeb1, Zeb2, E-cadherin, CCR7, Claudin-1, Fibronectin, Klf8, miR-9, miR-34, miR-200, N-cadherin, Occludin, PTEN, Slug, STK11, [62,63,66,72,79-82]”
• The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism (2014, background): “The transcriptional repressor Snail is a central driver of EMT and its expression correlates with metastasis and poor clinical prognosis [71] [72].”
• Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “Regulation of EMT-inducing transcription factors involves multiple layers of control that have been recently reviewed (66, 67).”
• EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “These complex programs are orchestrated and coordinated by a series of master EMT-inducing transcription factors (EMT-TFs), notably Snail, Slug, Twist and Zeb1, which have been explored in great experimental detail (De Craene and Berx, 2013; Lamouille et al., 2014).”
• The biology and role of CD44 in cancer progression: therapeutic implications (2018, background): “required to regulate CD44v expression [118].”
• IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014, background): “During cancer progression, EMT may contribute to increased invasiveness of cancer cells (29).”
• Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells (2013, background): “Although many signaling pathways have been identified for EMT (2, 24), the signals involved in the induction of MET have not been well characterized in embryonic development.”