Antibody Multispecificity Mediated by Conformational Diversity
By L. James, P. Roversi, Dan S. Tawfik. Science, 2003
729 citations recorded by the source corpus.
Subfields: Molecular Biology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/e164ffeb014aa7058f81b0a8a42576dcc648c9aa
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In Molecular Biology
- Vladimir N Uversky
- A. Keith Dunker
- Christopher J. Oldfield
- Haim J. Wolfson
- Jeffrey J. Gray
- Nelly Andrusier
- Efrat Mashiach
- Lukasz Kurgan
In Radiology, Nuclear Medicine and Imaging
- Efrat Mashiach
- Haim J. Wolfson
- Tong Li
- Ruth Nussinov
- Nelly Andrusier
- Jeffrey J. Gray
- Costas D. Maranas
- Robert J. Pantazes
Citations in the corpus
- Engineered antibody fragments and the rise of single domains (2005, background): “The challenges in engineering antibody binding sites are underlined by a series of remarkable structures showing how an antibody binding site is capable of interacting with several unrelated antigens through side chain and main chain rearrangemen”
- Principles of Flexible Protein-Protein Docking (2008, background): “7,8 The analysis can also identify possible hinge locations.”
- Turning a hobby into a job: How duplicated genes find new functions (2008, background): “Such multiple functions are not limited to enzymes: at least one known antibody possesses several binding-site conformations, each specific to a different antige”
- Antibody Polyreactivity in Health and Disease: Statu Variabilis (2013, background): “This model, in contrast to the induced-fit binding model, stipulates that an Ab molecule exists as equilibrium between its different structural variants (33, 37) (Fig.”
- Antibody Structure and Function: The Basis for Engineering Therapeutics (2019, background): “Correspondingly, one of the mechanisms of multispecificity lies in the plasticity of the antigen-binding site, which allows for the recognition of structurally unrelated epitopes by the same antibody [199,200].”
- Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification (2017, background): “Take for example the anti-hapten antibody, SPE7 591 (71).”
- Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling (2005, background): “conformations and thereby binds multiple, unrelated antigens, has been recently characterized (James et al., 2003).”
- Fano-resonant asymmetric metamaterials for ultrasensitive spectroscopy and identification of molecular monolayers. (2012, background): “In general, conformational rearrangements in biomolecular structures are required for matching the binding sites between the host and guest molecule”
- OptMAVEn – A New Framework for the de novo Design of Antibody Variable Region Models Targeting Specific Antigen Epitopes (2014, background): “Among the ten VRC01-like HIV broadly neutralizing antibodies isolated by RSC3 binding from different donors, only two residues from the same germline IGHV1-2*02 allele mature to the same amino acids [48].”