Age‐related production of new granule cells in the adult dentate gyrus

By T. Seki, Y. Arai. 1995

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Fred H. Gage
2. James Bradley Aimone
3. Wei Deng
4. Gerd Kempermann
5. E. Gould
6. Guo-li Ming
7. N. Kee
8. P. Taupin

Citations in the corpus

• New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “Blocking neurogenesis (the rate of which declines exponentially with agein”
• Adult neurogenesis: from precursors to network and physiology. (2005, result): “An age-related decline in DG neurogenesis has been confirmed in mice and rats using several BrdU labeling protocols (54, 208, 290, 306, 310, 499), whereas conflicting results have been reported for the SVZ (238, 253, 290, 543).”
• Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus (2001, background): “The number of dentate gyrus cells labeled with a single injection of BrdU decreases across the entire life span of the rat (Seki and Arai, 1995); this decrease was also observed in the current study between the 5-week-old rats in experiment 1 and the 10-week old rats in experiments 2 and 3.”
• Adult neurogenesis and neural stem cells of the central nervous system in mammals (2002, background): “ADULT NEUROGENESIS DECREASES WITH AGE Neurogenesis occurs constitutively throughout adulthood in the SVZ and the DG, but it has been reported that the rate of neurogenesis in the SVZ (Tropepe et al., 1997) and the DG (Seki and Arai, 1995; Kuhn et al., 1996) decreases with age in rodents.”
• Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus (2011, background): “This decline has been reported across mammalian species, including primates (Cameron and McKay, 1999; Hattiangady and Shetty, 2008; Kuhn et al., 1996; Leuner et al., 2007; Olariu et al., 2007; Seki and Arai, 1995).”
• Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years (2010, background): “We also made a first attempt to gather semi-quantitative information on how expression of such markers might change across the lifespan as previously described for rodents [6,12,16,33].”
• Early age-related changes in adult hippocampal neurogenesis in C57 mice. (2010, background): “A systematic study of early changes in neurogenesis similar to those performed in rats (Seki and Arai, 1995; Rao et al., 2006) is, to our knowledge, not available for the mouse.”
• Activity-dependent structural plasticity. (2009, background): “Thereby, they extend their dendritic branches through the inner and outer molecular layers (Kaplan and Bell, 1983; Cameron et al., 1993; Seki and Arai 1995) The larger dendrites provide new positions for axonal terminals to target on (Toni et al., 2007).”
• Stress and adult neurogenesis (2006, background): “in baseline adult neurogenesis (Seki and Arai, 1995; Kuhn et al., 1996; Cameron and McKay, 1999), it”
• Experience dictates stem cell fate in the adult hippocampus. (2011, unknown): “Specifically, neurogenesis decreases much more rapidly between the 1 and 3month groups (3–4- and 5–6-month-old animals) than between the 3 and 6 month groups (5–6- and 8–9-month-old animals) as demonstrated by several groups using different markers (Seki and Arai, 1995; Wu et al., 2008).”