Author response: Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

By Sonja Kroschwald, Shovamayee Maharana, Daniel Matějů, L. Malinovska, Elisabeth Nüske, I. Poser, Doris Richter, S. Alberti. 2015

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Principles and Properties of Stress granules (2016, background): “Moreover, both Hsp70 and Hsp40 proteins can localize to stress granules in yeast and mammalian cells [41,54,63,64].”
Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein (2016, background): “, 2015), stress granules in mammalian cells (Kroschwald et al., 2015), and ribonucleoprotein granules in fungi (Zhang et al.”
Stress-triggered phase separation is an adaptive, evolutionarily tuned response (2017, background): “…hypoxia, treatment with metabolic inhibitors, and other unfavorable changes trigger stress granule formation across a wide array of organisms (Cherkasov 1028 Cell 168, 1028–1040, March 9, 2017 ª 2017 Elsevier Inc. et al., 2013; Farny et al., 2009; Jain et al., 2016; Kroschwald et al., 2015).”
Liquid-Liquid Phase Separation in Disease. (2019, background): “Whereas bacteria and fungi appear to be able to reversibly solidify their cytoplasm, mammalian cells prefer to keep their cytoplasm in a liquid-like state (89, 111, 128).”