In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis
By I. Sekiya, J. Vuoristo, B. Larson, D. Prockop. Proceedings of the National Academy of Sciences of the United States of America, 2002
688 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/e076254ee434327f3b515050be04d70afa8be464
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Citations in the corpus
- The Regulation of Differentiation in Mesenchymal Stem Cells (2010, positive): “…osteo-stimulatory/modulatory effects of the TGF-b s as well as the BMPs have been well established in embryonic and adult mesenchymal cells (Johnstone et al. , 1998; Mackay et al. , 1998; Denker et al. , 1999; Barry et al. , 2001; Majumdar et al. , 2001; Noth et al. , 2002; Sekiya et al. , 2002).”
- Adult mesenchymal stem cells and cell-based tissue engineering (2002, background): “Another key factor known to play a role in chondrogenic lineage commitment and differentiation, and in the activation of cartilage-specific genes, is the transcription factor Sox 9 [89], whose mRNA levels are increased during chondrogenesis, particularly at early time points (G Boland et al.”
- Fracture healing as a post‐natal developmental process: Molecular, spatial, and temporal aspects of its regulation (2003, background): “A wealth of data also exists demonstrating that marrow stromal cells within the trabecular space are capable of undergoing differentiation into not only osteoblasts but chondrocytes as well [Jaiswal et al., 1997; Bianco et al., 2001; Sekiya et al., 2002].”
- Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. (2006, background): “We and other investigators have previously detected COL10A1 messenger RNA (mRNA) by sensitive techniques (11,12) in in vitro–differentiated MSC pellets, indicating that some features of chondrocyte hypertrophy are present in these cells (10); however, no further attention has been given to this obse”
- Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle (2007, background): “In addition, nucleated cells were plated at a density such that interactions between cell colonies could be avoided, thereby allowing a maximum rate of expansion (Colter et al. 2000, 2001; Sekiya et al. 2002a; Prockop et al. 2003).”
- Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. (2005, background): “Several authors have analyzed gene expression profiles of MSC and these studies have focused on 1) changes induced in the course of in vitro differentiation to osteogenic [46], chondrogenic [47,48], or adipogenic lineages [49,50], 2) direct comparison of gene expression profiles in different populat”
- Hydrogels as Extracellular Matrix Mimics for 3D Cell Culture (2009, background): “For example, during chondrogenesis fibronectin is downregulated within 7–12 days of hMSCs differentiating to chondrocytes by upregulating the production of matrix metalloproteinase 13 (MMP-13), which cleaves fibronectin (Sekiya et al., 2002).”