DNA demethylation for hormone-induced transcriptional derepression
By Mi‐Sun Kim, T. Kondo, I. Takada, Min-young Youn, Yoko Yamamoto, Sayuri Takahashi, Takahiro Matsumoto, Sally Fujiyama, Yuko Shirode, Ikuko Yamaoka and 5 more. Nature, 2011
120 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e051283267b9175c41630eccb3b84411bec41c17
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Citations in the corpus
- DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “Such PTH-induced DNA demethylation, and the subsequent transcriptional derepression, is impaired by Mbd4 knockout.(110) The above findings therefore suggest that MBD4 is indispensable for PTH-induced DNA demethylation in the CYP27B1 promoter in human cells.”
- Active DNA demethylation: many roads lead to Rome (2010, background): “Similarly, active DNA demethylation occurs at the cytochrome p450, subfamily 27B, polypeptide 1 ( CYP27B1 ) promoter in response to parathyroid hormone ( PTH”
- Targets and dynamics of promoter DNA methylation during early mouse development (2010, unknown): “Because increasing evidence suggest that DNA methylation at LCPs is constitutive and can be bypassed by activating signal”
- Molecular Mechanisms of Vitamin D Action (2012, background): “Negative regulation by VDR appears also to involve epigenetic mechanisms; for example, the CYP27B1 gene is repressed by 1,25D through epigenetic DNA demethylation [27].”
- The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, background): “In the latter case, this has been shown to involve the role of two DNA methyl-transferases in the inhibitory complex that in the presence of 1,25-(OH)2D serve to methylate CpG sites in the CYP27B1 promoter (44).”