SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans

By Rebecca L. Lamason, M. Mohideen, J. Mest, Andrew C. Wong, H. Norton, M. Aros, Michael J. Jurynec, Xianyun Mao, V. Humphreville, Jasper E. Humbert and 15 more. Science, 2005

1,054 citations recorded by the source corpus.

Subfields: Cell Biology, Dermatology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/e0475b76f7a5285c392780e326c767cda077f4d7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. N. Jablonski
2. Graham Coop
3. Joseph K. Pickrell
4. J. K. Pritchard
5. P. Hedrick
6. Torsten Günther
7. Abel S. Nunez
8. S. Lev-Yadun

In Dermatology

1. N. Jablonski
2. Graham Coop
3. Joseph K. Pickrell
4. J. K. Pritchard
5. Torsten Günther
6. Abel S. Nunez

In Nutrition and Dietetics

1. P. Hedrick
2. N. Jablonski
3. G. Chaplin
4. S. Lev-Yadun

Citations in the corpus

• Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system (2013, background): “Homozygous gol mutants show hypopigmentation in retinal pigment epithelium (RPE) and skin melanophores (21).”
• Using Environmental Correlations to Identify Loci Underlying Local Adaptation (2010, background): “Our top hit for a Western Eurasian effect (Figure 6) is the previously identified signal at SLC24A5 (Lamason et al. 2005).”
• The Genetics of Human Adaptation: Hard Sweeps, Soft Sweeps, and Polygenic Adaptation (2010, positive): “A number of other loci, such as the pigmentation loci SLC24A5 and KITLG [15,16], which are not clearly monogenic, do show striking sweep signals that match the qualitative predictions of the hard-sweep model.”
• Genetic Polymorphism in Heterogeneous Environments: The Age of Genomics (2006, background): “A single amino acid change in another gene (SLC24A5) has been shown to have a major influence on the difference in skin color between African and European human populations (Lamason et al. 2005).”
• A Map of Recent Positive Selection in the Human Genome (2006, background): “2 microcephaly genes namely, CDK5RAP2 in Yoruba and CENP in Europeans and east Asians.”
• Robust Identification of Local Adaptation from Allele Frequencies (2012, background): “The SNP with the most extreme value of XTX in the genome falls close to SLC24A5 (Nakayama et al., 2002; Lamason et al., 2005), while a SNP close to SLC45A2 is the second largest signal in the genome.”
• Human skin pigmentation as an adaptation to UV radiation (2010, background): “Regulatory mechanisms involve the control of the formation of melanosomes (the organelles in which melanins are produced and stored) (54, 55), and the production of the different types and mixtures of melanins.”