Fiber-Based Tissue Engineering: Progress, Challenges, and Opportunities
By Ali Tamayol, Mohsen Akbari, N. Annabi, A. Paul, Ali Khademhosseini, David Juncker. Biotechnology Advances, 2012
408 citations recorded by the source corpus.
Tissue engineering aims to improve the function of diseased or damaged organs by creating biological substitutes. To fabricate a functional tissue, the engineered construct should mimic the physiological environment including its structural, topographical, and mechanical properties. Moreover, the construct should facilitate nutrients and oxygen diffusion as well as removal of metabolic waste during tissue regeneration. In the last decade, fiber-based techniques such as weaving, knitting, braiding, as well as electrospinning, and direct writing have emerged as promising platforms for making 3D tissue constructs that can address the above mentioned challenges. Here, we critically review the techniques used to form cell-free and cell-laden fibers and to assemble them into scaffolds. We compare their mechanical properties, morphological features and biological activity. We discuss current challenges and future opportunities of fiber-based tissue engineering (FBTE) for use in research and clinical practice.
Subfields: Biomaterials, Surgery
View Paper: https://www.semanticscholar.org/paper/e009ebb4c480a96e91919f35df33fa5fd92a397b
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In Biomaterials
- Ali Khademhosseini
- N. Annabi
- K. Yue
- Ali Tamayol
- M. M. Álvarez
- G. Santiago
- Mohsen Akbari
- Yu Shrike Zhang
In Surgery
Citations in the corpus
- Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels (2015, methodology): “Recently, these techniques have been exte nsively used for engineering tissue engineering scaffolds with biomimetic mechanical pr operties [65-68].”
- Drug Delivery Systems and Materials for Wound Healing Applications (2018, positive): “Nanofibrous scaffolds can be produced using various techniques such as self-assembly, phase separation, and electrospinning [90].”
- Graphene-based materials for tissue engineering (2016, background): “Artificial fibrous structures which allow better nutrient transport are widely utilized in biomedical applications [77, 78].”