NMDA spikes in basal dendrites of cortical pyramidal neurons

By Jackie Schiller, G. Major, H. Koester, Y. Schiller. Nature, 2000

717 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/e003667c9caf36869067f01c14b0fc2dfc0f2b89

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Towards deep learning with segregated dendrites (2016, background): “Whether any such teaching signals exist in the real brain is unknown, though there is evidence that animals can represent desired behavioral outputs with internal goal representations (Gadagkar et al., 2016).”
Pyramidal neuron as two-layer neural network. (2003, neutral): “Box 1527 GR 711 10 Heraklion, Crete cell’s first layer of internal computation (Schiller et al., 2000; Wei et al., 2001).”
NMDA receptor-dependent multidendrite Ca(2+) spikes required for hippocampal burst firing in vivo. (2014, neutral): “, 1984) would become ineffective, leading to regenerative dendritic responses (Schiller et al., 2000).”
The principal features and mechanisms of dopamine modulation in the prefrontal cortex. (2004, background): “On the other hand, basal dendrites eminating from the soma of pyramidal neurons are much less well characterized electrophysiologically but are also a site of activity-dependent Ca influx (Schiller et al., 2000; Oakley et al., 2001a, 2001b; Young and Yang, 2004).”
Gating information by two-state membrane potential fluctuations. (2007, background): “Our initial observations showed that strong NMDA inputs can lead to large regenerative depolarizations similar to those seen in many neurons (Schiller et al. 2000).”
Computational subunits in thin dendrites of pyramidal cells (2004, neutral): “The absence of superlinear summation in these studies is notable, given that pyramidal neuron thin branches can respond to focal synaptic stimulation with regenerative NMDA, sodium, and/or calcium spikes that remain confined within the stimulated branc”
Active properties of neocortical pyramidal neuron dendrites. (2013, background): “…a large safety factor (Branco & Häusser 2011, Gordon et al. 2006, Larkum et al. 2009, Lavzin et al. 2012, Major et al. 2008, Nevian et al. 2007, Schiller et al. 2000).3 In vivo, investigators may already have made tantalizing preliminary sightings of events involving NMDA spike/plateaus,…”
Dendritic excitability and synaptic plasticity. (2008, neutral): “In summary, during development, small neurons that are effectively represented by a single compartment become large, complicated structures that can accommodate multiple functional compartments (400, 606, 671, 674, 868, 882).”
Pyramidal neurons: dendritic structure and synaptic integration (2008, background): “These are mediated by regenerative activation of NMDA receptors as a result of voltage-dependent relief of Mg 2+ bloc”
Dendritic spines and distributed circuits. (2011, neutral): “Local dendritic spikes (also known as ‘‘calcium spikes,’’ ‘‘calcium plateaus,’’ or ‘‘NMDA spikes’’) are generated by focal stimulation of a dendrite (Holthoff et al., 2004; Polsky et al., 2009; Schiller et al., 2000; Yuste et al., 1994).”
Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties (2011, background): “the models presented hereby could serve as a scaffold on which NMDA spikes can be fitted for, using a similar automated optimization framework, since NMDA spikes do not depend significantly on voltage gated channels [9].”