Sterile inflammation in the liver.

By P. Kubes, W. Mehal. Gastroenterology, 2012

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Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance. (2014, background): “DAMPs and sterile particulates, released from necrotic hepatocytes, might also contribute to elicit an inflammatory response in cirrhosis [103].”
Decoding cell death signals in liver inflammation. (2013, background): “Hepatic inflammation, which accompanies the majority of acute and chronic liver disorders, is a complex process that originates in response to a variety of stress conditions [1].”
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice (2017, background): “MCP-1 levels; pro-IL-1 and MCP-1 synthesis is regulated by NF-B, whose nuclear expression was also suppressed substantially in these experiments [9,18,22,44].”
Inflammatory responses and inflammation-associated diseases in organs (2015, background): “In SI, endogenous DAMPs are released to injured tissues and activate immune cells [136].”