Plant-derived exosomal microRNAs shape the gut microbiota
By Y. Teng, Yi Ren, Mohammed Sayed, Xin Hu, Chao Lei, Anil Kumar, E. Hutchins, J. Mu, Zhong-bin Deng, Chao Luo and 15 more. Cell Host and Microbe, 2018
877 citations recorded by the source corpus.
Summary The gut microbiota can be altered by dietary interventions to prevent and treat various diseases. However, the mechanisms by which food products modulate commensals remain largely unknown. We demonstrate that plant-derived exosomes-like nanoparticles (ELNs) are taken up by the gut microbiota and contain RNAs that alter microbiome composition and host physiology. Ginger ELNs (GELNs) are preferentially taken up by Lactobacillaceae in a GELN lipid-dependent manner and contain microRNAs that target various genes in Lactobacillus rhamnosus (LGG). Among these, GELN mdo-miR7267-3p-mediated targeting of the LGG monooxygenase ycnE yields increased indole-3-carboxaldehyde (I3A). GELN RNAs or I3A, a ligand for aryl hydrocarbon receptor (AHR), are sufficient to induce production of IL-22, which is linked to barrier function improvement. These functions of GELN RNAs can ameliorate mouse colitis via IL-22-dependent mechanisms. These findings reveal how plant products and their effects on the microbiome may be used to target specific host processes to alleviate disease.
Subfields: Cancer Research, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/df9c9acbaad449a89e5dd76c67bee7642539367e
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Citations in the corpus
- Plant exosome like nanovesicles: Emerging therapeutics and drug delivery nanoplatforms. (2020, background): “Similarly, ginger-derived PELNVs prefer to continue to dwell inside intestine upon oral administration.(88) In contrast, grapefruit-derived nanovectors were concentrated in macrophages of the lamina propria of cecum and colon of small intestine and later preferentially migrated to the liver as well.”
- Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe) (2019, background): “Moreover, microRNAs of ginger exosome-like nanoparticles (GELN) ameliorated mouse colitis by inducing the production of IL-22, a barrier function improvement factor [41].”