Using Force to Punch Holes: Mechanics of Contractile Nanomachines.

By Maximilian Brackmann, S. Nazarov, Jing Wang, Marek Basler. 2017

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Target highlights in CASP13: experimental target structures through the eyes of their authors (2019, background): “tails, the Type VI secretion system (T6SS), R-pyocins, and tailocins are multiprotein injection devices sharing a seringe-like architecture.(82-84)”
Protein Injection Machines in Bacteria (2018, unknown): “Although Hcp is required for the assembly of the extended sheath, the contracted sheath can still form in the absence of other T6SS components (Brackmann et al., 2017).”
A contractile injection system stimulates tubeworm metamorphosis by translocating a proteinaceous effector (2019, unknown): “MACs are an example of a Contractile Injection System (CIS); macromolecular machines that are specialized to puncture membranes and often deliver proteinaceous effectors into target cells (Brackmann et al., 2017; Taylor et al., 2018).”
Contractile injection systems of bacteriophages and related systems (2018, background): “Likewise, the production of a contractile injection system (e.g., T6SS) is a great expenditure of energy and material for a bacterium and its activation and triggering should be tightly regulated (Brackmann et al., 2017).”