Protein Injection Machines in Bacteria
By J. Galán, G. Waksman. 2018
226 citations recorded by the source corpus.
Many bacteria have evolved specialized nanomachines with the remarkable ability to inject multiple bacterially encoded effector proteins into eukaryotic or prokaryotic cells. Known as type III, type IV, and type VI secretion systems, these machines play a central role in the pathogenic or symbiotic interactions between multiple bacteria and their eukaryotic hosts, or in the establishment of bacterial communities in a diversity of environments. Here we focus on recent progress elucidating the structure and assembly pathways of these machines. As many of the interactions shaped by these machines are of medical importance, they provide an opportunity to develop novel therapeutic approaches to combat important human diseases.
Subfields: Endocrinology, Genetics, Molecular Biology
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Citations in the corpus
- Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria (2022, background): “We speculate (1) that tCISs may themselves play a role in ghost cell formation (for example, shedding of the cytoplasmic membrane) and/or (2) that tCISs in ghost cells are able to inject cargo into target cells, such as the many diverse organisms that are known to prey on cyanobacteria30 (Fig.”
- Structural Insight Into Conformational Changes Induced by ATP Binding in a Type III Secretion-Associated ATPase From Shigella flexneri (2018, background): “5 megadalton syringe-like complex, including a cytosolic ATPase complex, a cytoplasmic ring (C-ring), an inner membrane export apparatus, a basal body, and a translocation pore that is in the host cell membrane (Kubori et al., 1998; Galán et al., 2014; Deng et al., 2017; Galán and Waksman, 2018).”