Long non-coding RNAs and cancer: a new frontier of translational research?

By R. Spizzo, M. Almeida, A. Colombatti, George A. Calin. Oncogene, 2012

1,017 citations recorded by the source corpus.

Tiling array and novel sequencing technologies have made available the transcription profile of the entire human genome. However, the extent of transcription and the function of genetic elements that occur outside of protein-coding genes, particularly those involved in disease, are still a matter of debate. In this review, we focus on long non-coding RNAs (lncRNAs) that are involved in cancer. We define lncRNAs and present a cancer-oriented list of lncRNAs, list some tools (for example, public databases) that classify lncRNAs or that scan genome spans of interest to find whether known lncRNAs reside there, and describe some of the functions of lncRNAs and the possible genetic mechanisms that underlie lncRNA expression changes in cancer, as well as current and potential future applications of lncRNA research in the treatment of cancer.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/df591453ac8a59a6d5bb6f5f69095ddd01855853

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Xing Chen
2. Guiying Yan
3. Jianhua Yang
4. Liang-Hu Qu
5. Qinghua Cui
6. M. Gorospe
7. A. Lal
8. Junhao Li

In Molecular Biology

1. Xing Chen
2. Guiying Yan
3. Jianhua Yang
4. Liang-Hu Qu
5. Qinghua Cui
6. M. Gorospe
7. A. Lal
8. Junhao Li

Citations in the corpus

• ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data (2012, background): “Recent studies have revealed that the deregulation of miRNAs and lncRNAs is correlated with various human cancers and diseases (6,7), and that this deregulation is often due to the aberrant expression of TFs (39).”
• LncRNADisease: a database for long-non-coding RNA-associated diseases (2012, background): “Studies have reported that lncRNA dysfunctions are associated with a broad range of diseases (5), including cancers (11), cardiovascular diseases (12) and neurodegeneration diseases (13).”
• Long non-coding RNAs: a new frontier in the study of human diseases. (2013, background): “This length is a convenient cut-off to exclude small RNAs in RNA purification protocols [6,7].”
• Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB (2013, background): “Aberrant expression of several lncRNAs is associated with cancer [28,35,37,69].”