A-to-I editing of coding and non-coding RNAs by ADARs

By K. Nishikura. Nature reviews. Molecular cell biology, 2015

906 citations recorded by the source corpus.

Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but also frequently in non-coding regions that contain inverted Alu repeats. Editing of coding sequences can result in the expression of functionally altered proteins that are not encoded in the genome, whereas the significance of Alu editing remains largely unknown. Certain microRNA (miRNA) precursors are also edited, leading to reduced expression or altered function of mature miRNAs. Conversely, recent studies indicate that ADAR1 forms a complex with Dicer to promote miRNA processing, revealing a new function of ADAR1 in the regulation of RNA interference.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/df42bbd667bb5a7ea381bf32352d302553931f9a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Caterina Catalanotto
2. G. Zardo
3. C. Cogoni

Citations in the corpus

• Deciphering miRNAs’ Action through miRNA Editing (2019, background): “Indeed, nucleotide substitution within RNA sequences may occur in distinct regions of the transcript and affect the final protein product differently: through disruption of the reading frame, alterations of splicing sites or modifications of regions essential for RNA interference mechanisms [30].”
• MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions (2016, background): “This modification would inhibit maturation of miRNAs and thus reduce the cellular availability of mature miRNAs [68], even though no edited miRNAs have been identified in the pool of nucleolar miRNA to date [62,65,69,70].”