Overview of the voltage-gated sodium channel family
By F. H. Yu, William A. Catterall. Genome Biology, 2003
715 citations recorded by the source corpus.
Selective permeation of sodium ions through voltage-dependent sodium channels is fundamental to the generation of action potentials in excitable cells such as neurons. These channels are large integral membrane proteins and are encoded by at least ten genes in mammals. The different sodium channels have remarkably similar functional properties, but small changes in sodium-channel function are biologically relevant, as underscored by mutations that cause several human diseases of hyperexcitability.
Subfields: Cardiology and Cardiovascular Medicine, Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/df1db9351fa502cd52745b6d9e4a3e45f0d3e0c8
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cardiology and Cardiovascular Medicine
In Cellular and Molecular Neuroscience
In Molecular Biology
Citations in the corpus
- Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy (2006, neutral): “dtd" [ ]> Voltage-gated Na + channels in the brain are complexes of a 260-kDa α-subunit in association with auxiliary β-subunits (β1–β4) of 33 to 36 kD”
- The local differentiation of myelinated axons at nodes of Ranvier (2003, background): “Voltage-gated Na + channels are multimeric complexes that consist of a pore-forming α-subunit and one or more auxiliary β-subunit”
- Krüppel-Like Factor 9 Is Necessary for Late-Phase Neuronal Maturation in the Developing Dentate Gyrus and during Adult Hippocampal Neurogenesis (2009, neutral): “3 (Yu and Catterall, 2003), T-type calcium channel (CaV3.”
- The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins (2004, background): “Similar to transporters, channels allow movement of solutes down their electrochemical gradients [1, 4, 6, 9, 10, 14, 20 ].”
- Molecular physiology of cardiac repolarization. (2005, background): “3A) belong to the “S4” superfamily of voltage-gated ion channel genes (93, 172, 174, 573).”