Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

By E. Schrezenmeier, T. Dörner. Nature Reviews Rheumatology, 2020

1,273 citations recorded by the source corpus.

Subfields: Ophthalmology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/deb03fdd203d532bff6cd45fbb41f2bd69f39e04

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1. Miriam Merad
2. Nicolas Vabret
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5. N. Bhardwaj
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7. Baoying Huang
8. Brian D. Brown

Citations in the corpus

• Immunology of COVID-19: Current State of the Science (2020, positive): “CQ augments antigen processing for MHC class I and II presentation, directly inhibits endosomal TLR7 and TLR9, and enhances the activity of regulatory T cells (Garulli et al., 2008; Lo et al., 2015; Schrezenmeier and Dörner, 2020; Thomé et al., 2013a, 2013b).”
• Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial (2020, background): “As the pharmacological mechanism of CQ is further elucidated, its additional clinical applications, especially the antiviral activity, are also increasingly valued [13].”
• In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (2020, background): “Both hydroxychloroquine and chloroquine have immunomodulatory effects and can suppress the increase of immune factors [29, 30].”