In vivo imaging reveals an essential role for neutrophils in Leishmaniasis transmitted by sand flies
By N. Peters, J. Egen, N. Secundino, A. Debrabant, Nicola Kimblin, S. Kamhawi, P. Lawyer, M. Fay, Ronald N. Germain, D. Sacks. Science, 2008
835 citations recorded by the source corpus.
Infection with the obligate intracellular protozoan Leishmania is thought to be initiated by direct parasitization of macrophages, but the early events following transmission to the skin by vector sand flies have been difficult to examine directly. Using dynamic intravital microscopy and flow cytometry, we observed a rapid and sustained neutrophilic infiltrate at localized sand fly bite sites. Invading neutrophils efficiently captured Leishmania major (L.m.) parasites early after sand fly transmission or needle inoculation, but phagocytosed L.m. remained viable and infected neutrophils efficiently initiated infection. Furthermore, neutrophil depletion reduced, rather than enhanced, the ability of parasites to establish productive infections. Thus, L.m. appears to have evolved to both evade and exploit the innate host response to sand fly bite in order to establish and promote disease.
Subfields: Epidemiology, Infectious Diseases, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/de7d59e9c3d0691a4817ee6bdd874c4add6e4570
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
Citations in the corpus
- The sterile inflammatory response (2010, background): “Vasodilation can occur within seconds and fluid leakage and leukocyte extravasation within minutes to hours (8).”
- Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “…be similar to the situation in leishmaniasis when neutrophils engulf parasites at the site of infection and deliver them to macrophages, which take up live Leishmania parasites during phagocytosis of apoptotic neutrophils (van Zandbergen et al., 2004; Peters et al., 2008; John and Hunter, 2008).”