The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2.

By Douglas D. Thomas, Xiaoping Liu, S. Kantrow, J. Lancaster. Proceedings of the National Academy of Sciences of the United States of America, 2001

723 citations recorded by the source corpus.

Subfields: Biochemistry, Cardiology and Cardiovascular Medicine, Physiology

View Paper: https://www.semanticscholar.org/paper/de21590b8aaf2ec9a9d61503ac3cf261f601faf8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. E. Weitzberg
2. F. Larsen
3. B. Ekblom
4. K. Sahlin
5. Tomas A. Schiffer
6. S. Borniquel
7. J. Lundberg
8. Dean P. Jones

In Cardiology and Cardiovascular Medicine

1. P. Wardman

In Physiology

1. E. Weitzberg
2. J. Lundberg
3. F. Larsen
4. B. Ekblom
5. K. Sahlin
6. Tomas A. Schiffer
7. S. Borniquel
8. N. Benjamin

Citations in the corpus

• Radical-free biology of oxidative stress. (2008, background): “The free radicals nitric oxide and superoxide react to generate the nonradical oxidant peroxynitrite (179, 180).”
• Dietary inorganic nitrate improves mitochondrial efficiency in humans. (2011, background): “This binding, which is reversible and regulated by oxygen, may also serve to control reactive oxygen species (ROS) signaling and to regulate tissue oxygen gradients (Thomas et al., 2001).”
• A review of soil NO transformation: associated processes and possible physiological significance on organisms (2015, background): “According to 1161 Thomas et al. (2001, 2008) this directly points to an important regulatory 1162 relationship between NO signaling and tissue oxygen concentration.”
• Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. (2009, background): “The less reactive molecules such as nitric oxide (NO) can be released from innate immune cells specially macrophages and act on neighboring cells, leading to somatic mutations and cancer [56].”
• Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. (2010, background): “For example, greater homogeneity of perfusion relative to metabolic rate, perhaps as a consequence of an extension of the tissue O2 gradient due to NO-mediated inhibition of mitochondria closest to the capillary (14, 68), might reduce muscle metabolic perturbation.”
• Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects. (2007, background): “These short lifetimes imply very low steady-state or instantaneous cytosolic concentrations of both NOU and (especially) NO2U, and hence significant reaction of NOU with O2, and of NOU with NO2U, is unlikely in vivo [36,37], except perhaps under some extreme pathological conditions.”
• Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. (2009, background): “The NO so produced is capable of diffusion and may inhibit mitochondrial O2 consumption in the myocytes proximal to the capillary bed, promoting deeper diffusion of the available O2 (32, 59) and, therefore, enabling a more appropriate matching of local O2 delivery to O2 requirement.”