ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

By M. Raab, M. Gentili, Henry de Belly, H. Thiam, Pablo Vargas, A. J. Jimenez, F. Lautenschlaeger, Raphael Voituriez, A. Lennon-Duménil, N. Manel and 1 more. Science, 2016

853 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/de06414f6d745ea72ff2c3ee8ea6b42930b15c9f

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Citations in the corpus

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, neutral): “Importantly, YAP nuclear translocation is not due to the breakage of the nucleo-cytoplasmic barrier under force, as occurs under very high nuclear deformations (Denais et al., 2016; Raab et al., 2016; Skau et al., 2016).”
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer (2018, background): “It was recently reported that NE of the nucleus can be rapidly repaired by the endosomal sorting complexes required for transport III (ESC RT-III) complex (Denais et al., 2016; Raab et al., 2016), and this mechanism may provide similar protection to NEs of micronuclei.”
cGAS surveillance of micronuclei links genome instability to innate immunity (2017, neutral): “As chromatin activates cGAS, physiological ruptures in the primary nuclear membrane when cells migrate through tight interstitial spaces may also cause transient cGAS activation22,23.”
Physical traits of cancer (2020, background): “Migration of cancer cells (133–135), leukocytes (135), and primary mesenchymal stem cells (134) through pores smaller than their nucleus diameter results in severe compression and deformation of the nucleus, leading to loss of integrity of the nuclear envelope, herniation of chromatin via rupture th”
cGAS in action: Expanding roles in immunity and inflammation (2019, background): “For example, acute nuclear membrane damage such as that occurring during cell migration is perceived by cGAS, but rapid sealing of nuclear perforations through the ESCRTmachinery possibly prevents the generation of an inflammatory signal (63, 64).”
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis (2018, background): “Manel (73): Addgene plasmid 86675], mRuby2-NT-C1 [gift from M.”