Production of Polyunsaturated Fatty Acids by Polyketide Synthases in Both Prokaryotes and Eukaryotes
By J. Metz, P. Roessler, D. Facciotti, C. Levering, Franziska Dittrich, M. Lassner, R. Valentine, K. Lardizabal, F. Domergue, A. Yamada and 3 more. Science, 2001
722 citations recorded by the source corpus.
Subfields: Molecular Biology, Organic Chemistry, Pharmacology
View Paper: https://www.semanticscholar.org/paper/ddfd65b7e668c3f72d4a23093642342b2abc1ed5
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In Molecular Biology
Citations in the corpus
- Marine Biofilms: A Successful Microbial Strategy With Economic Implications (2018, background): “…a novel enzyme family necessary for the production of polyunsaturated fatty acids at low temperatures, whilst Thermotoga maritima, which grows at 90◦C, contains a novel glycerol ether lipid called 15,16-dimethyl-30-glyceryloxytriacontanedioic acid (De Rosa et al., 1989; Metz et al., 2001).”
- The biochemistry and molecular biology of lipid accumulation in oleaginous microorganisms. (2002, background): “The synthesis of these fatty acids may not occur via the usual FAS route but by a complete separate PKS (see Metz et al., 2001).”
- Lipids and lipid metabolism in eukaryotic algae. (2006, methodology): “Addition support for the polyketide synthase pathway was provided by the sequencing of 8500 randomly selected clones from a Schizochytrium cDNA library which failed to reveal the expected number and types of various desaturases in the aerobic pathway whereas polyketide synthase-homologous sequences ”
- Omega-3 long-chain polyunsaturated fatty acids and aquaculture in perspective (2015, background): “Primary production of DHA and 22:5n-6 in Schizochytrium is via a PUFA synthase (Metz et al., 2001), a series of 3 genes similar to those found in LC-PUFAproducing marine bacteria (Yazawa, 1996; Morita et al., 2000).”