Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes.

By Wei Wu, Sébastien Wieckowski, G. Pastorin, Monica Benincasa, Cédric Klumpp, J. Briand, R. Gennaro, M. Prato, A. Bianco. Angewandte Chemie, 2005

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Biomedical applications of functionalised carbon nanotubes. (2005, methodology): “Studies from our laboratories by Pantarotto et al. (2004a, b), Wu et al. (2005) and Kostarelos et al. (2007) using covalently functionalised CNTs (1,3-dipolar cycloaddition reaction chemistry) have reproducibly described that CNTs were uptaken by cells via pathways other than endocytosis.”
Applications of carbon nanotubes in drug delivery. (2005, methodology): “For this purpose, we have developed a new strategy for the multiple functionalisation of CNT with different types of molecules (Figure 4a) [42].”
Potential Applications of Carbon Nanotubes (2007, methodology): “At the carboxyl sites, researchers have attached amine [159, 160, 167–169] and thiol [161] groups, to link various biomolecules [154–156, 158] to the nanotubes.”
Gold nanoparticles in delivery applications. (2008, background): “delivery vehicles have been designed based on different nanomaterials, such as polymers [2], dendrimers [3], liposomes [4], nanotubes [5], and nanorods [6].”
Carbon Nanotubes in Biology and Medicine: In vitro and in vivo Detection, Imaging and Drug Delivery (2009, methodology): “We and many other groups successfully used well functionalized, serum stable carbon nanotubes for in vitro cellular uptake experiments without observing apparent toxicity [17, 18, 20, 51-57].”