Dynamics of B cells in germinal centres

By Nilushi S. De Silva, U. Klein. 2015

993 citations recorded by the source corpus.

Humoral immunity depends on the germinal centre (GC) reaction during which somatically mutated high-affinity memory B cells and plasma cells are generated. Recent studies have uncovered crucial cues that are required for the formation and the maintenance of GCs and for the selection of high-affinity antibody mutants. In addition, it is now clear that these events are promoted by the dynamic movements of cells within and between GCs. These findings have resolved the complexities of the GC reaction in greater detail than ever before. This Review focuses on these recent advances and discusses their implications for the establishment of humoral immunity.

Subfields: Immunology

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In Immunology

1. Hugo Gonzalez
2. Zena Werb
3. C. Hagerling
4. Pengfei Lu

Citations in the corpus

• GOATOOLS: A Python library for Gene Ontology analyses (2018, background): “…centers are an adaptive immune response because inside germinal centers, B cells proliferate expeditiously with the immunoglobulin variable region of the new B cells diversified by somatic hypermutation, resulting in the production of new generations of high affinity memory and plasma B cells 27 .”
• Roles of the immune system in cancer: from tumor initiation to metastatic progression (2018, background): “Upon activation in the germinal centers in lymphoid organs, B cells expressing high-affinity antibodies differentiate into antibody-secreting plasma cells and memory B cells that mediate humoral immunity against pathogens (De Silva and Klein 2015).”
• GERMINAL CENTER B CELL DYNAMICS (2016, neutral): “Although we briefly touch upon molecular aspects when appropriate, more thorough reviews of these topics are available elsewhere (Basso and Dalla-Favera, 2015; De Silva and Klein, 2015).”