Severe CD4+ T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy

By M. Guadalupe, E. Reay, S. Sankaran, T. Prindiville, J. Flamm, Andrew C Mcneil, S. Dandekar. Journal of Virology, 2003

959 citations recorded by the source corpus.

Subfields: Emergency Medicine, Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/dd1728cb4149bd1024ce1a8faa7bc91194ee56a1

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In Immunology

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Citations in the corpus

• Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4+ T Lymphocytes from Effector Sites in the Gastrointestinal Tract (2004, background): “In both of these individuals, identified after 4 and 6 wk of the estimated date of infection, mucosal CD4� T cell depletion was noted ( 19 ).”
• Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues (2014, neutral): “J Chromatogr B Analyt Technol Biomed Life Sci 831(1-2):248–257.”
• The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection (2009, background): “Some mathematical models (6–8) suggest that the rampant early infection simply destroys so many CD4 T cells in the gut (2, 9) and elsewhere that the cell substrate becomes limiting.”
• Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. (2008, background): “However, because T cell activation declines dramatically after initiation of antiretroviral therapy, long before significant restoration of CD4+ T cells in peripheral blood or tissues, T cell activation is unlikely to be solely a consequence of CD4+ T cell depletion in HIV infection [44, 45, 49].”
• Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production (2013, background): “Massive depletion of this cell population occurs during primary infection (Mattapallil et al., 2005), and long-term antiretroviral therapy (ART) only partially restores the memory CD4 T cell pool (Guadalupe et al., 2003; Brenchley et al., 2004).”
• HIV disease: fallout from a mucosal catastrophe? (2006, background): “and subsequent studies systematically examining mucosal target cell depletion and the kinetics of their activation and reconstitutio”