ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

By M. Greenway, P. Andersen, C. Russ, S. Ennis, S. Cashman, C. Donaghy, V. Patterson, R. Swingler, D. Kieran, J. Prehn and 5 more. Nature Genetics, 2006

682 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/dd1439f50746070a480ec0ab6fb715a246d6e3f9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. D. Cleveland
2. Thomas Tuschl
3. Berislav Zlokovic
4. M. Polymenidou

In Molecular Biology

1. P. Ivanov
2. Paul Anderson
3. D. Cleveland
4. Thomas Tuschl
5. Berislav Zlokovic
6. M. Hafner
7. S. Gerstberger
8. Shuo-Chien Ling

In Neurology

1. M. Polymenidou
2. D. Cleveland
3. Berislav Zlokovic
4. Shuo-Chien Ling
5. C. Iadecola
6. Mark P. Mattson
7. R. Bell
8. A. Sagare

Citations in the corpus

• A census of human RNA-binding proteins (2014, background): “neurological diseases ALS and cystic leukoencephalopathy, respectively (Greenway et al., 2006; Henneke et al., 2009; Skorupa et al., 2012; Thiyagarajan et al., 2012).”
• Angiogenin cleaves tRNA and promotes stress-induced translational repression (2009, background): “ALS-associated angiogenin missense mutations have reduced ribonuclease and angiogenic activity (Greenway et al., 2006; Wu et al., 2007).”
• ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now? (2019, background): “…processing Kwiatkowski et al., 2009; Vance et al., 2009 ANG Angiogenin RNA processing, neurite outgrowth, vascularisation, stress granule formation Greenway et al., 2006; Wu et al., 2007 SETX Senataxin DNA/RNA metabolism and helicase activity Chen et al., 2004; Hirano et al., 2011 MATR3 Matrin 3…”
• Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis (2013, positive): “Altogether, with additional ALS-linked mutations in the RNAbinding proteins angiogenin (Greenway et al., 2006), senataxin (Chen et al., 2004), and ataxin-2 (Elden et al., 2010), disruption in RNA homeostasis seems highly likely to play a central role in ALS pathogenesis.”
• A comprehensive review of amyotrophic lateral sclerosis (2015, background): “The age of onset for FALS is about a decade earlier than for sporadic cases.[2,107,289,299] There is also geographical loci form of ALS where prevalence is 50–100 times higher in certain locations than in any other part of the world.”
• Mutations in UBQLN2 cause dominant X-linked juvenile and adult onset ALS and ALS/dementia (2011, neutral): “Theotherwas a rabbit polyclonal antibody that we generated using a polypeptide of 17 amino acids from the amino terminus (amino acids 8–24, ubiquilin 2-”
• Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders (2011, background): “Angiogenin is another pro-angiogenic gene that is implicated in ALS because heterozygous missense mutations in angiogenin cause familial and sporadic AL”