Rational design of a potent, long-lasting form of interferon: a 40 kDa branched polyethylene glycol-conjugated interferon alpha-2a for the treatment of hepatitis C.

By P. Bailon, A. Palleroni, Carol Ann Schaffer, C. Spence, Wen-Jian Fung, J. E. Porter, G. Ehrlich, Wenkai Pan, Zhi-xin Xu, M. Modi and 3 more. Bioconjugate chemistry, 2001

605 citations recorded by the source corpus.

Subfields: Hepatology, Radiology, Nuclear Medicine and Imaging, Rheumatology

View Paper: https://www.semanticscholar.org/paper/dc88ce12f0c1e4b8b1c93f005c0459194f10f54b

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In Radiology, Nuclear Medicine and Imaging

1. Menči Kunstelj
2. Vladka Gaberc Porekar
3. S. Jevševar

Citations in the corpus

• PEGylation of therapeutic proteins (2010, methodology): “By employing CEX it was demonstrated that the marketed product PegIntron®, randomly conjugated with a 12-kDa linear PEG, contains 15 different PEG positional isoforms [74], while Pegasys®, randomly conjugated with a 40-kDa branched PEG, contains 4 main isoforms [27].”