PERSPECTIVE:SIGN EPISTASIS AND GENETIC CONSTRAINT ON EVOLUTIONARY TRAJECTORIES

By Daniel M. Weinreich, Richard A. Watson, L. Chao. 2005

585 citations recorded by the source corpus.

Subfields: Ecology, Evolution, Behavior and Systematics, Genetics, Sociology and Political Science

View Paper: https://www.semanticscholar.org/paper/dc782c72ef127dbb133d25457a9468e3361df06f

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Citations in the corpus

Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin (2013, unknown): “1324 Nonadditive interactions between mutations (epistasis) can exert a strong influence on the rate and direction of evolutionary change (1, 2).”
The Molecular Basis of Phenotypic Convergence (2014, background): “Because genes interact, the fitness effects of particular mutations often depend on the genetic background on which they arise (e.g., Weinreich et al. 2005).”
Germination, Postgermination Adaptation, and Species Ecological Ranges (2010, background): “…for fitness—correlational selection across loci such that the adaptive value of one locus depends on alleles at other loci—trajectories for adaptive evolution can be limited and can depend on the temporal sequence of fixation at particular loci (Poelwijk et al. 2007, Weinreich et al. 2005).”
Should evolutionary geneticists worry about higher-order epistasis? (2013, unknown): “For example, substantial attention has traditionally been paid to the role of positive and negative pairwise epistasis in the evolutionary persistence of genetic recombination [48], but under what circumstances will recombination be favored in the face of higher-order effects [40,49,50]? Moreover we”
Mechanistic approaches to the study of evolution: the functional synthesis (2007, background): “The number of strictly uphill paths is limited because some replacements are beneficial only in the presence of others, a phenomenon called sign epistasi”
The Evolution of Genetic Architecture (2006, background): “Weinreich et al. (2005) referred to the case where the order of fitness effects of a set of alleles is different in different genetic backgrounds as sign epistasis.”
Epistasis—the essential role of gene interactions in the structure and evolution of genetic systems (2008, background): “However, there has been a number of recent, more specialized reviews that cover topics such as the evolutionary impacts of epistasi”
Stability-mediated epistasis constrains the evolution of an influenza protein (2013, background): “Epistasis can play a key role in evolution, such as by constraining accessible evolutionary pathways (Weinreich et al., 2005; Kryazhimskiy et al., 2011) and increasing the role of contingency in adaptation (Blount et al.”