Tumor imaging by means of proteolytic activation of cell-penetrating peptides.

By Tao Jiang, E. Olson, Q. Nguyen, M. Roy, P. Jennings, Roger Tsien. Proceedings of the National Academy of Sciences of the United States of America, 2004

812 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/dbfccf85c91d0afa955931d9d01618194676904a

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Citations in the corpus

Tissue-penetrating delivery of compounds and nanoparticles into tumors (2009, neutral): “Jiang et al. (2004) have described a design for tumor-homing peptides in which a cationic cell-penetrating peptide is tethered to a negatively charged sequence that blocks the cell-penetrating activity.”
Illuminating the metastatic process (2007, methodology): “This work does not indicate that proteases are not active in tumours; protease-activated fluorescent probes ( Box 3 ) have been used to directly image the activity of tumour-associated MMPs and cathepsin proteases in whole animal imaging studie”
Cell-penetrating peptides: design, synthesis, and applications. (2014, background): “Activatable CPPs (ACPPs) are in vivo targeting agents which contain a polycationic CPP linked through a specific proteolytically cleavable linker (succinoyl or 6-aminohexanoyl) to a neutralizing polyanionic part in a hairpin-structure-based conformation.(173) The biodistribution of Cy5-labeled ACPPs”
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, methodology): “…pep- tides, which are activated by proteolysis and carry a fluorescent cargo that accumulates in cells that are in the vicinity of active MMPs (Jiang et al., 2004), have been used successfully to visualize MMP-2 and -9 activity in cell culture systems and in mouse xenograft models and show…”
CNS Delivery Via Adsorptive Transcytosis (2008, background): “Such strategies may exploit specific cell features, such as extracellular receptors or enzymes ( 82 ), or use small or large cell-binding ligands (e.g.”
C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration (2009, background): “CPP derivatives with cationic and anionic modules linked by a protease-sensitive linker have been developed for tumor-selective delivery (10).”
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer (2011, neutral): “New technologies based on fluorescence resonance energy transfer (FRET) (Jiang et al., 2004), magnetic resonance imaging (MRI), positron emission tomography (PET) and single photon emission computed tomography (SPECT) (for a review, see Scherer et al., 2008a) are being developed to image the…”
The multiple uses of fluorescent proteins to visualize cancer in vivo (2005, background): “NEAR INFRARED probes that can be activated by protease”
Fluorescence imaging in vivo: recent advances. (2007, methodology): “Enzyme-mediated uptake of probes Tsien and colleagues [41 ] designed an enzymemediated ‘gating’ strategy to selectively deliver the”
Basics and recent advances in peptide and protein drug delivery (2013, neutral): “The specificity is often gained via activation of the CPP in the tumor environment or by conjugating a targeting moiety to the CPP [219,220,301].”
Engineered Protease-resistant Antibodies with Selectable Cell-killing Functions* (2013, background): “UnlikeMMPs, which can cleave short peptides with recognition motifs as small as 6 amino acids (65), IdeS does not cleave peptide analogues of the IgG hinge (25).”