C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

By T. Teesalu, K. Sugahara, V. R. Kotamraju, Erkki Ruoslahti. Proceedings of the National Academy of Sciences of the United States of America, 2009

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Tissue-penetrating delivery of compounds and nanoparticles into tumors (2009, positive): “To investigate this proteolysis hypothesis, we first examined whether iRGD binds to PPC1 cells in a CendR-dependent manner after being treated by a protease to expose a C-terminal arginine or lysine; PPC1 cells have substantial levels of neuropilin-1 expression (Teesalu et al., 2009).”