Cell mediated immune responses in Tuberculosis

By A. Cooper. Annual Review of Immunology, 2009

1,160 citations recorded by the source corpus.

Tuberculosis is primarily a disease of the lung and dissemination is dependent upon productive infection of this critical organ. Upon aerosol infection with Mycobacterium tuberculosis (Mtb), the acquired cellular immune response is slow to be induced and to be expressed within the lung. This slowness allows infection to become established and forces the acquired response to be expressed in a context of an inflammatory site that has been initiated and modulated by the bacterium. Mtb has a variety of surface molecules that interact with the innate response and this interaction along with the auto-regulation of the immune response by several mechanisms results in less than optimal control of bacterial growth. To improve current vaccine strategies we must understand the factors that mediate induction, expression and regulation of the immune response in the lung. We must also determine how to induce both known and novel immunoprotective responses without inducing immunopathologic consequences.

Subfields: Epidemiology, Infectious Diseases, Surgery

View Paper: https://www.semanticscholar.org/paper/db98e5aad783616f45409d6a4bb2e47518618abe

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In Epidemiology

1. A. O’Garra
2. R. Wilkinson
3. Eric G. Pamer
4. C. Shi
5. M. Berry
6. Finlay W Mcnab
7. Paul S. Redford
8. C. Bloom

In Infectious Diseases

1. A. O’Garra
2. R. Wilkinson
3. Eric G. Pamer
4. C. Shi
5. M. Berry
6. Finlay W Mcnab
7. Paul S. Redford
8. C. Bloom

In Surgery

1. A. O’Garra
2. Kenneth A. Jacobson
3. R. Wilkinson
4. Eric G. Pamer
5. C. Shi
6. M. Berry
7. Finlay W Mcnab
8. Paul S. Redford

Citations in the corpus

• Hematoxylin and eosin staining of tissue and cell sections. (2008, background): “Como na maioria das infecções causadas por patógenos intracelulares, sabe-se que a resposta imunológica mediada por células tem um papel fundamental na proteção contra a TB (Orme et al. 1992; Cooper 2009).”
• The immune response in tuberculosis. (2013, background): “tuberculosis infection is dependent on IL-12 (p40/p35) (11, 12, 87, 124, 226), which is mainly secreted by M.”
• Monocyte recruitment during infection and inflammation (2011, background): “tuberculosis is an inhaled, respiratory pathogen that infects macrophages and DC”