Hydrocortisone therapy for patients with septic shock.

By C. Sprung, Djillali Annane, D. Keh, R. Moreno, Mervyn Singer, K. Freivogel, Y. Weiss, J. Benbenishty, A. Kalenka, H. Forst and 5 more. New England Journal of Medicine, 2008

1,945 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/db83c2821bfec5aa77e716afeb496b2771a1eb43

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Citations in the corpus

Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine (2008, methodology): “He has received grant support from the European Commission, Takeda, and Eisai Corporation.”
Sepsis and septic shock. (2018, background): “115 Systematic reviews 116–118 and guidelines from the European Society of Intensive Care Medicine and the Society of Critical Care Medicine suggest some benefit of using corticosteroids in sepsis only if shock is present.”
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “high-dose glucocorticoids in patients with septic shock remains controversial and may even be harmful (340).”
Drotrecogin alfa (activated) in adults with septic shock. (2012, methodology): “We used an adaptive design(22) that allowed us to increase the sample size to maintain adequate statistical power, since some trials involving patients with severe sepsis showed lower-thanexpected mortality.(19,23,24) To reduce the risk of assignment bias, we concealed study-group assignments before”
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before‐After Study (2017, background): “reported to vary between about 72 and 120 h.(37,54) In the VANISH (Vasopressin vs Noradrenaline as Initial Therapy in Septic Shock) trial, the median time to shock reversal was 45 h (interquartile range, 23-75 h).”
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 (2017, background): “In contrast, a large, European multicenter trial (CORTICUS) that enrolled patients with systolic blood pressure of <90 mm Hg despite adequate fluid replacement or need for vasopressors had a lower risk of death than the French trial and failed to show a mortality benefit with steroid therapy [302].”
BTS guidelines for the management of community acquired pneumonia in adults: update 2009 (2009, background): “with severe sepsis found no survival benefit with hydrocortisone treatment.(332) [Ib] This was a heterogeneous group, but a significant number had respiratory infections.”
Critical care - where have we been and where are we going? (2013, background): “Repeatedly, new approaches have failed to live up to the promise shown in preclinical or single-center studies: tight glucose control [23,24], moderate-dose steroids in septic shock [25,26], and activated protein C [27,28], to name just a few.”