Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens

By D. Garsin, J. Villanueva, J. Begun, Dennis H. Kim, C. Sifri, S. Calderwood, Gary Ruvkun, Frederick M. Ausubel. Science, 2003

612 citations recorded by the source corpus.

Subfields: Aging

View Paper: https://www.semanticscholar.org/paper/db5f293f33cd7d20e3a8b20b3be5a808bba4b254

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. C. Kenyon
2. Catherine Au
3. Siu Sylvia Lee
4. D. Gems
5. Frederick M. Ausubel
6. Valerie Reinke
7. E. Troemel
8. S. Chu

Citations in the corpus

• p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans (2006, background): “Enterococcus faecalis and Staphylococcus aureus [12].”
• Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism (2013, background): “Culture of C. elegans with Bacillus subtilis increases lifespan (Garsin et al., 2003), suggesting that this microbe is less pathogenic toC. elegans than E. coli.”
• The plasticity of aging: insights from long-lived mutants. (2005, background): “The antibacterial genes are also interesting since bacterial proliferation contributes to the death of C. elegans (Garigan et al., 2002; Gems and Riddle, 2000) and daf-2 mutants are resistant to pathogens (Garsin et al., 2003).”