Long-axis specialization of the human hippocampus.

By Jordan L Poppenk, Hallvard Røe Evensmoen, Morris Moscovitch, Lynn Nadel. Trends in Cognitive Sciences, 2013

1,047 citations recorded by the source corpus.

Investigation of the hippocampus has historically focused on computations within the trisynaptic circuit. However, discovery of important anatomical and functional variability along its long axis has inspired recent proposals of long-axis functional specialization in both the animal and human literatures. Here, we review and evaluate these proposals. We suggest that various long-axis specializations arise out of differences between the anterior (aHPC) and posterior hippocampus (pHPC) in large-scale network connectivity, the organization of entorhinal grid cells, and subfield compositions that bias the aHPC and pHPC towards pattern completion and separation, respectively. The latter two differences give rise to a property, reflected in the expression of multiple other functional specializations, of coarse, global representations in anterior hippocampus and fine-grained, local representations in posterior hippocampus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/db5b2d188d1506f88911feef2867d7e6f2035c87

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

The restless engram: consolidations never end. (2012, background): “By contrast the bias in the posterior hippocampus is for the representation of detail (Poppenk et al., 2013).”
Episodic Memory and Beyond: The Hippocampus and Neocortex in Transformation (2016, neutral): “Similarly, encoding novel events, or forming relational associations between random items, is associated with aHPC activation, possibly because such activities typically involve higher-order conceptual processing, whereas encoding familiar or repeated events relies less on such conceptual processes ”
Age Differences in Hippocampal Subfield Volumes from Childhood to Late Adulthood (2015, background): “In spite of possible age differences in hippocampal form (Gogtay et al., 2006) and length (Insausti et al., 2010), the anatomical landmarks that denote the head (see Poppenk et al., 2013) are present in children and adults alike.”
Neural reactivation in parietal cortex enhances memory for episodically linked information (2018, methodology): “A cued recall test, administered on day 2, revealed that retention was enhanced for tested objects in the retrieval practice condition relative to the restudy condition for both groups [one cycle, t(31) = 3.”
The molecular and systems biology of memory. (2014, neutral): “By contrast the bias in the posterior hippocampus is for the representation of detail (Poppenk et al., 2013).”
The hippocampus and related neocortical structures in memory transformation. (2018, background): “Based on these di ﬀ erences, investigators (see [95]) have suggested that the posterior hippocampus (pHPC) is suited for coding (representing) ﬁ ne grained, local features of an event which underlie rich perceptually-based memory representations (details), whereas the anterior hippocampus (aHPC)…”
Interplay of hippocampus and prefrontal cortex in memory (2013, neutral): “These and several related findings have led to the recent proposal that the dorsal–ventral (posterior–anterior in humans) axis of the hippocampus may contain a topographic representation of more general features of memories [43,45].”
Selectivity in Postencoding Connectivity with High-Level Visual Cortex Is Associated with Reward-Motivated Memory (2017, background): “In regards to high-value information, mechanisms of systems-level memory consolidation may be centered on the anterior hippocampus, as prior research has implicated the anterior hippocampus in memory for affective/motivationally relevant information (Poppenk et al., 2013).”
Functional segregation of rostral and caudal hippocampus in associative memory (2025, unknown): “…(HC) or its’ homologs in non-human animals is mainly involved in spatial memory and navigation (Hartley et al., 2003; Nadel et al., 2013; Poppenk et al., 2013) memory, whereas the rostral HC is associated to the emotional and stress-related response (de Kloet et al., 2018; Dorey et al.,…”