Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study.

By Yvette I. Sheline, Deanna M. Barch, J. Donnelly, J. Ollinger, Abraham Z. Snyder, Mark A. Mintun. Biological Psychiatry, 2001

1,255 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/da9045bc3f718d596eaa7366effbcb12dbbbfa49

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Citations in the corpus

Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. (2006, result): “As would be predicted by our results, in both depression and PTSD, hyperactivation of the amygdala occurs to both conscious and unconscious threat (Davidson et al., 2002; Hull, 2002; Rauch et al., 2000; Sheline et al., 2001).”
Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. (2004, background): “More recent studies have examined specific cognitive(11-13) and affective(13-16) processes and, using functional magnetic resonance imaging (fMRI), have combined cognitive activation paradigms with antidepressant treatments.(17,18) A fundamental neuropsychological impairment in depression is a moodc”
Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus (2010, methodology): “Participants were screened using criteria described previously (34, 35), resulting in 18 individuals withmajor depression (11males, 7 females; mean age, 35.”
Neurocircuitry of Mood Disorders (2010, background): “In MDD subjects the amygdala shows exaggerated hemodynamic responses during exposure to sad words (Siegle et al, 2002), explicitly presented sad faces (Drevets et al, 2001; Fu et al, 2004), masked fearful faces (Sheline et al, 2001), and masked sad faces (Fu et al, 2004).”
Emotion Regulation in Depression (2014, background): “(2012) reported no group difference in initial amygdala response to the emotional pictures, which suggests that only the downregulation of amygdala activity is affected by a history of depression (see also Sheline et al., 2001).”
You Gotta Work at It (2014, background): “It could also augment the effects of common antidepressants, which directly address mechanisms of reactivity (e.g., Sheline et al., 2001).”
The neurobiology of psychedelic drugs: implications for the treatment of mood disorders (2010, background): “, and attenuates the amygdala response to the presentation of images showing sad faces in patients with depressio”
Clinical biomarkers in drug discovery and development (2003, methodology): “This hyperarousal was normalized by treatment with the serotonin-reuptake inhibitor and antidepressant sertraline in an uncontrolled pilot study with fMR”
Cognitive therapy vs. medications for depression: Treatment outcomes and neural mechanisms (2008, background): “Changes in neurotransmitter availability are known to trigger various other changes in the brain, such as decreases in amygdala activit”
The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. (2005, background): “Accordingly, depressed patients have left amygdala hyperactivity, even when processing stimuli outwith conscious awareness, and this increased amygdala activation is normalized with antidepressant treatment [329].”