Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study.

By C. Fu, Steven C. R. Williams, A. Cleare, M. Brammer, N. Walsh, Jieun Kim, C. Andrew, E. Pich, Pauline M. Williams, L. Reed and 3 more. Archives of General Psychiatry, 2004

826 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/188140668985c198794922d6422abceaf7b77acf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

In Pharmacology

Citations in the corpus

The neurobiology of psychedelic drugs: implications for the treatment of mood disorders (2010, background): “, and attenuates the amygdala response to the presentation of images showing sad faces in patients with depressio”
The Nature, Diagnosis, and Treatment of Neuroticism (2014, background): “, selective serotonin reuptake inhibitors) produce dampening effects on neuroticism (Fu et al., 2004; Harmer et al., 2009; Harmer, Mackay, Reid, Cowen, & Goodwin, 2006; Murphy, Yiend, Lester, Cowen, & Harmer, 2009; Quilty, Meusel, & Bagby, 2008) and possibly to a lesser extent on extraversion (McCab”
Reconsidering Anhedonia in Depression: Lessons from Translational Neuroscience (2010, background): “…while multiple studies have shown that individuals with depression exhibit increased amygdala activation in response to negatively-valenced stimuli (Fu et al., 2004; Siegle et al., 2006; Siegle et al., 2002; Siegle et al., 2007), newer evidence suggests that this amygdala activity may occur…”
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008, methodology): “Similarly, increased activity in amygdala was observed during presentation of masked fearful (Sheline et al. 2001) and masked sad faces (Fu et al. 2004) in MDD patients versus healthy controls, and higher activity was seen in lateral orbital cortex following negative emotional stimuli in the…”
Cognitive therapy vs. medications for depression: Treatment outcomes and neural mechanisms (2008, background): “Findings from fMRI studies suggest that symptom decreases produced by SSRIs lead to a functional decrease in limbic reactivity to emotional face”
A meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression (2012, neutral): “For the amygdala and hippocampus, enhanced activity was reported mainly in the parahippocampal gyrus extending to the amygdala (Fu et al., 2004; Hooley et al., 2009; Surguladze et al., 2005) or in the sublenticular extended amygdala (Abler et al.”
Neurocircuitry of Mood Disorders (2010, background): “In MDD subjects the amygdala shows exaggerated hemodynamic responses during exposure to sad words (Siegle et al, 2002), explicitly presented sad faces (Drevets et al, 2001; Fu et al, 2004), masked fearful faces (Sheline et al, 2001), and masked sad faces (Fu et al, 2004).”
Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity (2009, neutral): “As a model of emotional processing we chose a variation of a face perception task that is known to activate the amygdala, superior temporal sulci (STS), and fusiform cortex in a mood-dependent manner (20).”