Mutational switch of an IL-6 response to an interferon-γ-like response

By A. P. Costa-Pereira, Silvia Tininini, B. Strobl, T. Alonzi, J. Schlaak, H. Is’harc, I. Gesualdo, S. J. Newman, I. Kerr, V. Poli. Proceedings of the National Academy of Sciences of the United States of America, 2002

250 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/da888d8813b03c6bf87422e930f36fc637ee515a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Hua Yu
2. R. Jove
3. Bin Liu
4. K. Shuai
5. D. Pardoll
6. S. Grivennikov
7. Antoni Ribas
8. Jacques Banchereau

In Oncology

1. Hua Yu
2. D. Pardoll
3. R. Jove
4. Bin Liu
5. K. Shuai
6. D. Gabrilovich
7. M. Karin
8. S. Grivennikov

Citations in the corpus

• Regulation of JAK–STAT signalling in the immune system (2003, background): “A similar alteration of the IL-6 response has also been observed in Stat3 −/− cells, in which STAT1 activation is prolonge”
• Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity (2005, background): “An increase in Stat1 activity in cultured Stat3 −/− macrophages has been reported, in keeping with opposing activities often observed between these two Stat protein”
• The STAT3 isoforms α and β have unique and specific functions (2004, background): “STAT3-null mouse embryo fibroblasts (MEFs) show an IFN-γ-like response to IL-6, including prolonged STAT1 activation, induction of IFN-γ target genes and antiviral activit”