Aging and Wound Healing

By Ankush Gosain, L. DiPietro. World Journal of Surgery, 2004

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Factors affecting wound healing (2010, background): “…to the wound site; (4) suitable angiogenesis; (5) prompt re-epithelialization (re-growth of epithelial tissue over the wound surface); and (6) proper synthesis, cross-linking, and alignment of collagen to provide strength to the healing tissue (Gosain and DiPietro, 2004; Mathieu et al., 2006).”
Inflammation in Chronic Wounds (2016, result): “Although the healing response in aged subjects is slower, animal and human studies have shown that the final result is comparable in quality to young subjects [53,54].”
Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. (2007, background): “Since the provisional fibrin-based matrix is relatively devoid of fibroblasts, the processes of migration, proliferation and ECM production are the key steps in the regeneration of a functional dermis [11].”
Zinc in Infection and Inflammation (2017, background): “Delayed wound healing in the elderly constitutes a major clinical and economic challenge, especially as the aging population grows [151].”