Physiology and pathophysiology of purinergic neurotransmission.

By G. Burnstock. Physiological Reviews, 2007

1,588 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/da414f44d02f96eb45fc77b47d7fe7584d8823e3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. E. Thies
2. H. Zempel
3. E. Mandelkow
4. Guo-Yuan Yang
5. Yongting Wang
6. Jixian Wang
7. Yuanyuan Ma
8. F. Di Virgilio

In Neurology

1. Guo-Yuan Yang
2. Yongting Wang
3. Jixian Wang
4. Yuanyuan Ma
5. Maiken Nedergaard
6. J. Scholz
7. E. Mandelkow
8. E. Thies

In Physiology

1. Clifford J. Woolf
2. E. Mandelkow
3. Guo-Yuan Yang
4. Yongting Wang
5. Jixian Wang
6. Yuanyuan Ma
7. J. Scholz
8. H. Zempel

Citations in the corpus

• The P2X7 Receptor in Infection and Inflammation (2017, positive): “In higher mammals, the nucleotide receptor family (P2 receptors, P2Rs) is comprised of two subfamilies: G protein-coupled metabotropic P2Y (P2YR) and ligand (ATP)-gated ionotropic P2X (P2XR) receptors (see Table 1; Burnstock, 2007).”
• Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture (2010, background): “Once released, ATP acts as a transmitter that binds to purinergic receptors, including P2X and P2Y receptor”
• The neuropathic pain triad: neurons, immune cells and glia (2007, background): “In contrast, P2Y receptors are slow G protein–coupled receptors with a high affinity (in the nanomolar range) for ATP that trigger a variety of second-messenger signaling pathways, resulting in a prolonged signal duratio”
• The biphasic function of microglia in ischemic stroke (2017, positive): “P2X4 and P2X7 receptors are predominantly expressed on microglia and mediate microglia activation after cerebral ischemia, hypoxia or hypoxia-ischemia (Burnstock, 2007; Cavaliere et al., 2003; de Rivero Vaccari et al., 2012; Del Puerto et al., 2013; Li et al., 2011; Wixey et al., 2009).”
• Purinergic signalling and disorders of the central nervous system (2008, background): “and it is now recognized that ATP is a cotransmitter in all nerve types in both the peripheral and central nervous system”
• Aβ Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines (2010, methodology): “We also tested extracellular ATP (100 M, 3 h), which functions as a stress signal and induces Ca 2 influx via P2 receptors and has been implicated in neurodegenerative disease (Burnstock, 2007).”