Nuclear Activity of MLA Immune Receptors Links Isolate-Specific and Basal Disease-Resistance Responses

By Qianhua Shen, Y. Saijo, S. Mauch, C. Biskup, S. Bieri, B. Keller, H. Seki, Bekir Ülker, I. Somssich, Paul Schulze-Lefert. Science, 2007

749 citations recorded by the source corpus.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/da203dcb53a96db65788a1c43cf3733037d9cfba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Plant Science

1. I. Somssich
2. Shree P. Pandey
3. T. Eulgem
4. David Mackey
5. A. Bent
6. Jukon Kim
7. Xujun Chen
8. Sébastien Duplessis

Citations in the corpus

• WRKY transcription factors: evolution, binding, and action (2019, positive): “The barley mildew A (MLA) locus encodes CC-type NLR (CNL) proteins, which mediates against the powdery mildew fungal pathogen Blumeria graminis (Shen et al. 2007).”
• HIGS: Host-Induced Gene Silencing in the Obligate Biotrophic Fungal Pathogen Blumeria graminis[W][OA] (2010, background): “In the case ofAvra10, a role of the encoded signal-peptide free protein inside host cells has been proposed, which could theoretically also be explained by secretion of the corresponding fungal transcript into the host (Shen et al., 2007).”
• Firefly Luciferase Complementation Imaging Assay for Protein-Protein Interactions in Plants1[C][W][OA] (2007, background): “The application of FRET and BRET in plant biology, however, has encountered significant difficulties despite sporadic successes (Shen et al., 2007).”
• Elicitors, effectors, and R genes: the new paradigm and a lifetime supply of questions. (2007, background): “It was observed that recognition of AvrA10 induces MLA10 association with specific WRKY factors that otherwise repress defense expression (156).”
• WRKY Transcription Factors: Molecular Regulation and Stress Responses in Plants (2016, background): “HvWRKY1/2 are activated when fungal avirulence AVR10 effector is recognized by resistance protein MLA (mildew-resistance locus A) in the cytoplasm and the subsequent association of MLA with the WRKYs in the nucleus (Shen et al., 2007).”
• Plant immunity: towards an integrated view of plant–pathogen interactions (2010, background): “thaliana RPS4 proteins localize to both the cell cytoplasm and nucleus, and nuclear accumulation is required for their functio”
• Fungal effector proteins. (2009, background): “The effector-dependent association between barley Mla10 and WRKY TFs contributes to Mla10-mediated resistance and host cell death at attempted fungal infection sites (108).”
• Networks of WRKY transcription factors in defense signaling. (2007, background): “Consistent with this, IIa representatives from rice (OsWRKY71) and barley (HvWRKY1, HvWRKY2) were found in vivo to engage in homomeric associations [22 ,30].”
• Poplar and Pathogen Interactions: Insights from Populus Genome-Wide Analyses of Resistance and Defense Gene Families and Gene Expression Profiling (2009, background): “…and mutant analyses has demonstrated that these WRKYs play important roles in resistance to disease caused by fungal biotrophs (Li et al., 2006; Shen et al., 2007). bZIP (basic region leucine-zipper) proteins are also a large family of transcription factors with 75 members in Arabidopsis and…”
• Functional analysis of a cold-responsive rice WRKY gene, OsWRKY71 (2016, background): “…and AtWRKY60 are negative regulators of resistance to the hemibiotrophic bacterial pathogen Pseudomonas syringae (Xu et al. 2006) and the barley WRKYs HvWRKY1 and HvWRKY2 are negative regulators of the basal defense response against the fungal pathogen Blumeria graminis (Shen et al. 2007).”
• Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “It is known that one single WRKY gene often responds to several stress signals, and then participates in the regulation of several different physiological processes during which it seems to act disparately as a negative or positive regulator (Eulgem et al., 2000; Xu et al., 2006; Eulgem and Somssich”
• The Role of WRKY Transcription Factors in Plant Immunity[W] (2009, background): “MLA was shown to physically interact in the nucleus with HvWRKY1 and -2, two repressors of PAMP-triggered basal defense, thereby interfering with WRKY repressor functions and leading to resistance against the powdery mildew fungus (Shen et al., 2007).”