ARF proteins: roles in membrane traffic and beyond

By C. D’Souza-Schorey, P. Chavrier. Nature reviews. Molecular cell biology, 2006

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Microvesicles: mediators of extracellular communication during cancer progression (2010, background): “Consistent with its role in regulating tumor invasion in cell and animal models (D’Souza-Schorey and Chavrier, 2006; Hu et al., 2009; Muralidharan-Chari et al., 2009b), ARF6 activation promotes microvesicle shedding, whereas dominant inhibition of ARF6 activation attenuates microvesicle shedding…”
Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression (2018, background): “One of the most well-described regulators of MV shedding is ADP-ribosylation factor 6 (ARF6), a member belonging to the Ras superfamily of small GTPases (67, 68).”
ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles. (2009, background): “What might be the cellular basis by which ARF6 promotes cell invasion? First, ARF6 has been implicated in regulation of invadopodia turnover [4].”
Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles (2016, background): “GBF1 is a guanine nucleotide exchange factor and activator of the small GTPase Arf1 (ADPribosylation factor 1), which regulates traffic in the secretory pathway by mediating the recruitment of downstream effectors to membranes [44,45].”